Talk by Sami Sebastian Brandt, University of Copenhagen

Large Scale Statistical Structure Recovery in Cryogenic Electron Microscopy


Cryogenic electron microscopy intends to reconstruct biological particles on the nanometer scale from transmission images taken by a transmission electron microscope. In contrast to the image reconstruction problems in other fields of tomographic imaging, the reconstruction problem has the particular characteristics of having a huge number of 2D projection images of a bio-particle, with structural variations, while the projection geometry of the projections is unknown and random. This setting makes the statistical inversion problem particularly challenging where the state-of-the-art reconstruction methods require CPU months for processing a single particle. In this talk, we will discuss the reconstruction problem and the state-of-the-art, present our contributions, and sketch an outline for the future.

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